ALOX15 and gastric cancer: For example, Zhang et al. reported that CDDP and paclitaxel promoted the secretion of miR-522 in exosomes from cancer-associated fibroblasts, suppressed arachidonate lipoxygenase 15 (ALOX15), and decreased the accumulation of lipid-ROS (toxic lipid peroxides) in gastric cancer cells, resulting in reduced sensitivity to anticancer drugs [69].