In respect to laser photocoagulation, anti-VEGF drugs have been recently reported to display a decreased incidence of retinal detachment, probably thanks to a faster decrease in VEGF levels [18], a reduced rate of optic atrophy and amblyopia [19], and less eye complications even if burdened by a higher retreatment incidence [20]. This evidence concerns the gene VEGFA and Leber hereditary optic neuropathy.