He et al. did not observe in a case-control study about association between IL-4/IL-4R and genetic variations, GC risk, and their prognostic values [77] (Table 2); however, interestingly in another study, Noto et al. showed that IL4/IL13 signaling via IL4Ra regulate metaplasia in GC [78] (Table 3). Here, IL4R is linked to gastric cancer.