VEGFA and central nervous system cancer: Therefore, payloads should be chosen among drugs such as temozolomide, BCNU, nimustine, vincristine, the VEGF inhibitors shown above, and other known cancer drugs, such as lysine-specific demethylase-1 (KDM1A) inhibitors (Figure 10), which induced the differentiation and apoptosis of glioma stem cells, in a treatment developed by Dr. Takayoshi Suzuki at Osaka University (Suita, Japan) [45].