Bae et al. analyzed the functional role of Beclin-1 in autophagy and demonstrated that in Hela cell lines, the reduction of the tumor protein, translationally controlled 1 (TPT1/TCTP), promoted autophagy by enhancing the cooperation between Beclin-1 and UVRAG, which stimulates autophagosome formation and maturation [144]. Here, BECN1 is linked to neoplasm.