In another study, 59% of BI-ALCL cases showed mutations in ≥ one member of the JAK/STAT pathway, including STAT3 (38%), JAK1 (18%), and STAT5B (3%), and in negative regulators of this pathway, such as SOCS3 (6%), SOCS1 (3%), and PTPN1 (3%) [128]. The gene discussed is JAK1; the disease is anaplastic large cell lymphoma.