The standard therapy for newly diagnosed CHL patients in the U.S.A. has been the doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) chemotherapy regimen, although recent studies have replaced bleomycin with brentuximab vedotin (BV), an anti-CD30 antibody linked to a toxin [41,42]. Here, TNFRSF8 is linked to classic Hodgkin lymphoma.