In fact, despite the strong cytotoxicity exhibited against wild-type and mutant IDH1 U-87 MG cells and patient-derived glioblastoma cells NULU and ZAR, Cyn has proven to selectively inhibit cancer cell lines and only weakly affect the proliferation of fibroblasts (Detroit 551 and explanted primary cells) and Chang liver cells [47]. Here, IDH1 is linked to cancer.