Thus, in mice with apoA-II amyloidosis, an increased expression of heat shock protein A5 (HSPA5), as well as numerous endoplasmic reticulum stress-related proteins, including activating transcription factor 4 and 6 (ATF4 and ATF6), eukaryotic translation initiation factor 2 alpha kinase 3 (EIF2AK3), X-box-binding protein 1 splicing (XBP1S), DNA-damage inducible transcript 3 (DDIT3), and autophagy protein 5 (ATG5) were found [127]. The gene discussed is APOA2; the disease is amyloidosis.