Surprisingly, whereas the transfection levels of rVPwt plasmid in HK-2 cells are around 30% (Figure 2A,B), we could observe a 65% reduction in ZIKV infection (Figure 2C), suggesting that molecules acting at the paracrine level can be found in supernatants of HK-2 cells overexpressing viperin to control ZIKV infection. Here, RSAD2 is linked to Zika virus infectious disease.