Subsequently, viperin has been shown to be involved in other viral infection restriction, such as influenza virus, hepatitis C virus (HCV), Sindbis virus (SINV), human immunodeficiency virus (HIV), West Nile virus (WNV), Japanese encephalitis virus (JEV) [6,9,10,11,12,13], and more recently, dengue virus (DENV) and Zika virus (ZIKV) [13,14,15,16,17]. The gene discussed is RSAD2; the disease is viral infectious disease.