In their paper, Nitsche et al. reported that the independent predictors of the presence of CA in AS patients are a longer QRS duration and a lower voltage/mass ratio and history of CTS; moreover, patients with AS-amyloidosis had a lower prevalence of coronary and peripheral artery disease, a significantly decreased functional capacity as measured by a 6 min walking test (6-MWT) and significantly elevated cardiac biomarkers (NT-proBNP and hsTnT) [50]. The gene discussed is NPPB; the disease is aortic valve stenosis.