Comparison of normal and tumor tissue at long-term culture showed increased expression of IGF1R (5-fold, p < 0.0001) and IGFBP6 (3.5-fold, p < 0.01), whereas IGFBP1 (4-fold, p < 0.05), IGFBP3 (2.5-fold, p < 0.01) and IGFBP4 (4-fold, p < 0.01) were downregulated in tumor slices (Figure S4D). This evidence concerns the gene IGFBP3 and neoplasm.