TNF and infection: These dysfunctions are associated with enhanced inflammation and metabolic imbalance, which may significantly disturb the normal response of the immune system to infections, resulting in a pro-inflammatory state [3,5], and leading often to chronic inflammatory processes, explained by the well-known fact that pro-inflammatory cytokines, such as tumor necrosis factor (TNFα), interleukine-6 (IL-6), and interleukine-1β (IL-1β), are upregulated in the adipose tissue of individuals with MS.