KHK and fatty liver disease: Furthermore, a recent study showed that KHK deletion had different effects depending on the tissue: specific hepatic KHK deletion did not reduce fructose drinking, but protected from fatty liver, whereas the deletion of KHK only in the jejunum led to reduced fructose intake, but hepatic steatosis was promoted due to reduced intestinal fructose metabolism and increased entry of fructose into the liver [21].