In preoperative molecular FNAC diagnostics, the aggressiveness of cancers with the most frequently occurring mutations (BRAF, RAS, RET/PTC, TERT, PAX8/PPAR-γ, RET proto-oncogene) is correlated with the extent of the planned surgical treatment [32,33,34,35,36,37,38,39,40]. This evidence concerns the gene PAX8 and cancer.