Overall, the novel RIV–BIM hybrids presented here show interesting properties as potential anti-AD drugs, some of them bearing diverse and important anti-AD hallmarks (inhibition of cholinesterases, inhibition of amyloid self-aggregation and Cu(II)-induced aggregation, as well as reduction of ROS and Aβ42 toxicity in neuronal cells). The gene discussed is BCHE; the disease is Alzheimer disease.