A first, by the authors called the “reproductive” group (21% to 23% of their two young study populations at median age 28), characterized by higher SHBG and lower BMI as well as insulin levels, therefore, compatible with here proposed HH-PCOS population, and a second “metabolic” group (37–39% of patients), characterized by higher BMI, glucose, and insulin levels but lower SHBG and, therefore, fully compatible with the here proposed H-PCOS entity. This evidence concerns the gene INS and polycystic ovary syndrome.