When stratified by the APOE genotype, there were no significant differences among the control, MCI, and AD groups in the APOE3E3 carriers by one-way ANOVA (8.99 ± 0.85 nm, 8.79 ± 0.58 nm, and 8.72 ± 0.64 nm, respectively, F(2, 99) = 1.40, p = 0.252, Figure 3B). The gene discussed is APOE; the disease is Alzheimer disease.