TLR4 and neoplasm: The authors reported efficient tumor elimination at effector:target ratios of 1:10 (TLR2 and TLR4 MOTO-CARs), 1:5 (TLR4 MOTO-CAR), and 2:1 (TLR2 and TLR4 MOTO-CARs), compared to non-transfected macrophages (mock) controls.