These findings suggest that TNF antagonism may induce an immune deviation from the Th1/Th17 phenotype to the Th2 phenotype and that CD4 T-cell modulation can be effective in reversing the psoriatic phenotype, as IL-4 therapy produced a marked clinical improvement by increasing the number of IL-4-producing CD4 T cells in psoriasis patients [61]. Here, CD4 is linked to psoriasis.