Patients with active SLE display increased serum levels of type I IFNs, which correlate well with disease activity [26,27] and the subsequent increases in the expression levels of IFN-stimulated genes (ISGs) (the IFN signature) seen in their peripheral blood mononuclear cells (PBMCs) [28,29]. Here, IFNA1 is linked to systemic lupus erythematosus.