Therefore, we performed Western blot analysis of the HNF1A, GATA4, GATA6, FOXA1, and FOXA2 proteins in pancreatic cancer cell lines with downregulated SOX9 expression for the purpose of investigating the potential functional link between SOX9 and the expression of these protein master regulators of pancreatic development (Figure 2G,H and Figure S3G). This evidence concerns the gene GATA4 and familial pancreatic carcinoma.