Importantly, Umesh et al. revealed that a stiffness-associated increase in glioma cells’ proliferation depends on activation of EGFR; as demonstrated, enhancing the microenvironmental stiffness results in augmented EGFR/Akt expression, phosphorylation, and inhibition of EGFR-associated pathways, and weakens stiffness-mediated cellular effects. This evidence concerns the gene EGFR and central nervous system cancer.