In particular, NHE1 immunoreactivity was reduced in the CA1 region (Figure 5(B2), arrow) and markedly increased in the alveus region of the subiculum and mossy fiber in the CKD 10-wk rats (CKD 10 wks, F1,8 = 37.77, p < 0.001; one-way ANOVA; Figure 5(B1), *; Figure 5(B3), arrow, E). The gene discussed is SLC9A1; the disease is chronic kidney disease.