ACHE and Alzheimer disease: The most effective strategy to treat AD is the use of inhibitors of acetylcholinesterases [9] as these enzymes hydrolyze acetylcholine (ACh), which is needed for nerve transmission, however, a normal phenomenon in certain pathological conditions is that its excessive activities lead to cholinergic deficit on one hand whereas, on the other hand, it enhances the formation of amyloid peptide [10].