IL10 and central nervous system cancer: Additionally, IL10, which was found in our study to be upregulated in regrown tumors compared with primary implanted tumors, was shown to promote glioma cell growth and invasion [32,33] Moreover, IL-10 was shown to suppress proliferation, cytokine production, and migration of effector T-cells, driving T-cell exhaustion and thus creating an immunosuppressing environment in the tumor [34,35].