AKT1 and glioblastoma: IL-17 has been found to promote migration, extracellular matrix degradation, and invasion of cancer cells, including GBM cells, through the activation of PI3K–AKT [42,43] and STAT3 signaling [43,44], as well as through the elevation of expression of the matrix metalloproteinases MMP-2 and MMP-9 [42].