This is an important area for investigation because CRF and endogenous opioids act in concert in LC to respond to a stressor: first, CRF is released onto LC causing depolarization and increased discharge and anxiety-like behavior, and upon stressor termination, endogenous opioids act on their receptors to suppress LC output and facilitate a return to a more normative behavioral state [25,32]. Here, CRH is linked to Anxiety.