The top five drugs with significant anti-similarity to AD were: naftifine, an anti-mycotic drug; moricizine, used to treat arrhythmias; ketoconazole, an anti-mycotic drug; perindopril, an ACE inhibitor; and fexofenadine, an antihistamine drug (Figure 3, Table 2). The gene discussed is ACE; the disease is Alzheimer disease.