Interestingly, Dong et al. have previously shown that by inhibiting hippocampal ACE, perindropil was able to significantly prevent cognitive impairment in a model of AD induced by intracerebroventricular injection of Aβ1–40, as well as in PS2APP-transgenic mice, and was associated with the suppression of microglia and astrocyte activation, and a reduction in oxidative stress [34]. This evidence concerns the gene ACE and Cognitive impairment.