The top five drugs in this category were: irinotecan, an anticancer chemotherapeutic; cyproheptadine, an antihistamine; teniposide, an anti-cancer drug; phenoxybenzamine, an alpha-receptor blocking agent used for the treatment of hypertension; and pitavastatin, an HMG-CoA reductase inhibitor (Figure 4, Table 3). This evidence concerns the gene HMGCR and hypertensive disorder.