While as an anti-inflammatory agent this polyphenol counteracts NF-κB activation and suppresses inflammation via different mechanisms [146], as an anticancer drug curcumin exhibits tumor suppressive function by inhibiting proliferation, drug resistance and promoting apoptosis through inhibition of IKK-mediated NF-κB activation and other factors (i.e., AP-1, MAPK, AKT, COX-2, P-gp) [17]. The gene discussed is NFKB1; the disease is neoplasm.