They also showed that NIK stabilization induced DNA (cytosine-5)-methyltransferase 3A (DNMT3A) and Notch upregulation, as well as downregulation of Myocyte Enhancer Factor 2C (MEF2C) and RelA, suggesting that NIK stabilization could be an attractive therapeutic strategy to treat specific AML tumors. Here, DNMT3A is linked to acute myeloid leukemia.