IL6 and cancer: It is known that NF-κB is the major player between inflammation and cancer [63,64] and contributes to evading apoptosis and sustaining cell survival by inducing the secretion of pro-inflammatory cytokines (i.e., TNFα, Interleukin 6 (IL-6), Interleukin 1β (IL-1β) and regulating heme oxygenase-1 (HO-1) expression and inducible nitric oxide synthase (iNOS) activation in the TME [65,66,67].