Those tumor-infiltrating pDCs are poor IFN-I producers, because of cytokine dysregulation by transforming growth factor β (TGF-β) and TNF-α secretions in the tumor microenvironment that inhibit the IFN-I secretion of pDCs through the inhibition of IRF-7 expression [84], and favors Treg expansion [1,80,81]. Here, TNF is linked to neoplasm.