NOS2 and pancreatic neoplasm: In fact, TAMs were shown to express Inducible Nitric Oxide Synthase (iNOS), for instance, after local low-dose irradiation or CpG oligodeoxynucleotides (CpG ODN) treatment in a model of pancreatic cancer, leading to the expression of adhesion molecules on the endothelium and to subsequent T cell infiltration [20,21].