Common translocations in children with B–ALL include t(12;21) [ETV6–RUNX1](25%), t(1;19) [TCF3–PBX1] (5%), t(9;22) [BCR–ABL1] (3%) and translocations involving the MLL gene with various fusion partner genes (5%). This evidence concerns the gene RUNX1 and acute lymphoblastic leukemia.