Genes that demonstrated high levels of activity in tumor enteroids following LPS stimulation included KH domain-containing, RNA-binding, signal transduction-associated protein 3 (KHDRBS3), Flap endonuclease GEN homolog 1 (GEN1), krev interaction trapped-1 (KRIT1), Centromere protein F (CENPF), ciliogenesis and planar polarity effector complex subunit 1 (CPLANE1), and tyrosine-protein kinase (STYK1). The gene discussed is CPLANE1; the disease is neoplasm.