Genes that demonstrated high levels of activity in IBD enteroids following LPS stimulation included the DENN domain containing 5B (DENND5B), serine/threonine/tyrosine-interacting-like protein 1 (STYXL1), regenerating islet-derived protein 3-gamma-like (REG3G), and protein S100-A16 (S100A16). Here, DENND5B is linked to inflammatory bowel disease.