Among the exclusive genes in the Latin American population, we identified 10 genes related to cancer as novel altered genes potentially associated with HPV-associated PSCC: KMT2C, SMARCA4, PTPRB, AJUBA, CR1 (in 20% of the tumors, each), KMT2D, CIC, NBEA, FAM135B, and GTF2I (in 15% of the tumors, each). This evidence concerns the gene KMT2D and cancer.