FBXW7 and cancer: Among the altered genes found in at least 15% of tumors, 18 (NOTCH, FAT1, TP53, CDKN2A, FBXW7, CASP8, SMARCA4, PTPRB, KMT2C, CR1, AJUBA, KMT2D, MTOR, NBEA, LRP1B, FAM135B, GTF2I, and CIC) had already been linked to different types of cancer [38].