The production of sTNFR1 and sTNFR2 by TNBC cells, and their reported ability to limit inflammatory processes, have led us to question whether the two soluble receptors can modulate the pro-inflammatory and tumor-related characteristics of the cancer cells, which are induced by the ligand of TNFR1 and TNFR2, namely TNFα. This evidence concerns the gene TNFRSF1B and neoplasm.