Whereas TNFα and IL-1β are minimally expressed in normal breast tissues, their expression levels in breast cancer patients are relatively high, and are increased as disease progresses [18,20,23,24,25,26,27], and studies in breast cancer animal models provided evidence to their causative roles in promoting disease course [18,19,28,29,30,31,32]. This evidence concerns the gene IL1B and breast carcinoma.