Thus, on the one hand, there are some studies associating KLF2 with an oncogenic role, as in the case of multiple myeloma [60] or pancreatic tumors [61], whereas in other models, it seems to have a character closer to tumor suppression, as in hepatocarcinoma [62,63] or, more recently, in renal cancer [64]. This evidence concerns the gene KLF2 and plasma cell myeloma.