Locally or systematically activated inflammation also increases soluble growth factors, such as epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and vascular endothelial growth factor (VEGF), thus activating dormant micrometastases, stimulating angiogenesis, inducing propagation and supporting the growth of residual or newly colonized cancer cells [51,52]. This evidence concerns the gene EGF and cancer.