CD4 and melanoma: Consistent with the findings for melanoma, the markedly increased infiltration levels of immune response cells (e.g., central memory CD4/8 T cells, effector memory CD8 T cells, and cytotoxic cells) and decreased infiltration levels of immune suppressive cells (e.g., regulatory T cells) were observed in NSCLC patients harboring HSPG2 mutations (all p < 0.05; Figure S7A,B).