It has been revealed that the perlecan protein exhibits vital roles in multiple biological behaviors via the interaction with prolargin, laminin, collagen type IV, transthyretin, etc. Several recent studies have demonstrated that HSPG2 overexpression was associated with invasion, metastasis, and an inferior survival outcome in triple-negative breast cancer [14], acute myeloid leukemia [15], glioblastoma [16,17], oligoastrocytoma [18], and oligodendroglioma [18]. This evidence concerns the gene HSPG2 and glioblastoma.