HSPG2 and neoplasm: In this study, we observed that an elevated infiltration of immune response cells (e.g., CD8 T cells and M1 macrophages) and a decreased infiltration of immune suppressive cells (e.g., regulatory T cells and mast cells) were enriched in HSPG2- mutated patients, which suggests that HSPG2 mutations mediate a favorable immune infiltration and tumor microenvironment.