Studies have shown that DHM has anticancer activity against gefitinib-resistant and gefitinib-insensitive NSCLC cells, which causes apoptosis in NSCLC cell lines (A549 and H1975) by activating caspase-9/-7/-3 and cleaving poly ADP-ribose polymerase (PARP) [29]. This evidence concerns the gene CASP9 and non-small cell lung carcinoma.