CLCN4 and malignant colon neoplasm: DHM has been found to delay colon cancer formation by maintaining lower butyrate levels during the hyperproliferative phase and by acting as an activator of chloride channels (CFTR, CLCN3, and CLCN4); 100 mg/kg DHM can also improve the dominant intestinal flora in high-fat-diet–fed cancer mice and reduce the susceptibility to colon cancers [91].