PLAU and osteosarcoma: DHM has been found to reduce the expression of transcriptional factorS SP-1 and NF-κB from the cytoplasm to the nucleus via the ERK pathway, thereby reducing the ability of SP-1 and NF-κB to bind to the downstream uPA promoter, resulting in downregulation of uPA expression, and ultimately suppressing osteosarcoma metastasis [46].