CASP3 and ovarian carcinoma: DHM also impairs the motility and invasiveness of ovarian cancer SKOV3 and A2780 cells and stimulates the c-Jun N-terminal kinase (JNK)/ERK-caspase-3 pathway, leading to apoptosis by upregulating the cleaved caspase-3 and Bax/Bcl-2 ratio in ovarian cancer cells [55].