In cutaneous squamous cell carcinoma, DHM can inhibit the phosphorylation of malat1-transcription factor EB (TFEB), thereby activating TFEB nuclear translocation, increasing the activity of the TFEB reporter gene and the expression of autophagy-related genes and decreasing the expression of MALAT1, thereby disturbing MALAT1 homeostasis and promoting autophagic cell death in A431 cells [103]. This evidence concerns the gene TFEB and cutaneous squamous cell carcinoma.