In particular, median TMB was significantly lower in tumors with BRAF class 1 alterations (median TMB = 3.91 mut/Mb) than in those harboring class 2 (median TMB = 6.73 mut/Mb, p = 0.004) and class 3 (median TMB = 10.57 mut/Mb, p < 0.001) alterations, as well as compared to that of NSCLC with BRAF alterations of any known functional class (p = 0.006) and unselected NSCLC (p = 0.03) (Figure 2B). Here, BRAF is linked to non-small cell lung carcinoma.