Finally, among NSCLC patients with BRAF class 3 alterations (n = 46), the most frequent co-altered genes were MUC16 (14/20, 70%), TP53 (30/46, 65%), ZFHX4 (13/20, 65%) and TTN (12/20, 60%) (Figure 4C). Here, TTN is linked to non-small cell lung carcinoma.