For example, STK11 and KEAP1 alterations, which we found with higher prevalence in tumors harboring class 2 and class 3 BRAF alterations than in those with class 1 alterations, where they were almost absent, have been associated with high TMB but immune “cold” tumor microenvironment and poor prognosis [64,65,66]. This evidence concerns the gene KEAP1 and neoplasm.