Of note, the deregulation of miR-1a, miR-499, miR-133, miR-223 and miR-155 converges on the activation of the PKA-mediated phosphorylation of CREB, whose activation is associated with two well-recognized radiation-induced heart diseases, i.e., cardiac hypertrophy and heart failure [25,26], both strictly related to the alteration in Ca2+ signaling. Here, CREB1 is linked to heart disorder.