CXCR1 and colorectal carcinoma: Interestingly, ARNTL KO and NR1D1 KO both significantly reduced cell apoptosis and migration (p < 0.001, AUC compared to WT) which together with dysregulated expression of EMT related genes points towards the regulation of CC and MACC1 in CRC possibly affecting cell motility (Figure 1G,H).