Interestingly, ARNTL KO and NR1D1 KO both significantly reduced cell apoptosis and migration (p < 0.001, AUC compared to WT) which together with dysregulated expression of EMT related genes points towards the regulation of CC and MACC1 in CRC possibly affecting cell motility (Figure 1G,H). Here, MACC1 is linked to colorectal carcinoma.