We further investigated the effect of CC KO in elements of cancer- and metastasis-related pathways such as the cell cycle (MYC), cell proliferation (HRAS), cell death (TP53), EMT (ECAD and SNAI1), metastasis (CD44, CD133 and MACC1), as well as clock- and cancer-related genes (SIRT1 and AKT1). Here, SIRT1 is linked to cancer.