Overall effect size showed that NRP1 overexpression was not correlated with AFP levels higher than 20 ng/mL (AFP, OR 0.75, 95% CI 0.45–1.26, p = 0.27), patients older than 50 years (age, OR 0.82, 95% CI 0.59–1.15, p = 0.25), male population (gender, OR 1.24, 95% CI 0.86–1.79, p = 0.25), presence of more than one nodule (tumor number, OR 1.50, 95% CI 0.93–2.44, p = 0.10) and tumor size larger than 5 cm (tumor size, OR 1.01, 95% CI 0.76–1.34, p = 0.97). Here, AFP is linked to neoplasm.