Interestingly, heterogeneity associated with OS and NRP1 meta-analysis in CRC patients was substantially reduced for the subgroup involving studies with less than or equal to 200 patients (I2 = 48.01%, Q-test p = 0.12); however, NRP1 overexpression was not correlated with OS (HR 1.02, 95% CI 0.99–1.06, p = 0.21) (Table 3B). The gene discussed is NRP1; the disease is colorectal carcinoma.