NFKB1 and cancer: The IPA of genes significantly decreased by 974 treatment revealed altered xenobiotic metabolism signaling, cancer drug efflux, and IL6 and NFκB signaling (Figure 4D, Supplementary Table S4), all of which have been reported to play a role in stemness and chemoresistance [20,36,37]; furthermore, the cellular senescence pathway was significantly downregulated by 974 treatment (Figure 4D).