BL, intermediate L, mn-BLL11q and DHL form a DZ-like cluster, GCB-DLBCL and FL/DLBCL are more LZ-like while FL distributes mostly across INT and LZ states, IRF4-break LCL are bimodally distributed between DZ and LZ (and partly, PBLb) and ABC-DLBCL show PBL properties. The gene discussed is IRF4; the disease is diffuse large B-cell lymphoma.