In addition to the basic types BL, DLBCL and FL, we characterized provisional intermediate entities with specific genetic lesions affecting driver genes of lymphoma genesis, namely, double hits of MYC and BCL2 combining genetic features characteristic for BL and FL, of rearranged IRF4, a key player of plasma cell activation, as well as Chr. This evidence concerns the gene IRF4 and diffuse large B-cell lymphoma.