HGBL-DH/TH (high grade B-cell lymphoma with double/triple hits) harbor simultaneous translocations of MYC and BCL2 (DHL BCL2) or MYC and BCL6 (DHL BCL6), which associate with aggressive clinical course and inferior prognosis [6,61]. Here, BCL2 is linked to B-cell non-Hodgkin lymphoma.