For example, alterations in TET2 gene, one of the more commonly mutated genes in myeloid neoplasms, specifically co-occurred with NEB gene variations in control MPN patients, with the odds ratio for the co-occurrence being 11.6 times higher than that seen in MPN patients with SCs (p = 0.0138). The gene discussed is NEB; the disease is myeloproliferative neoplasm.