Compared to de novo disease, post-MPN AML is more likely to be provoked by aberrant chromosomal changes, including complex karyotypes, monosomies, and 17p deletion, and mutations in epigenetic regulators, such as IDH1/2, TET2, ASXL1, and EZH2 [8]. Here, ASXL1 is linked to myeloproliferative neoplasm.