Noteworthy, acquired mono- or biallelic somatic RUNX1 variants, including deletions, missense, splice site, frameshift, and nonsense variants, correlate with worse prognosis in sporadic AML, MDS, and T-cell acute lymphoblastic leukemia (T-ALL) [20,21,22,23]. The gene discussed is RUNX1; the disease is acute lymphoblastic leukemia.