Nowadays, pathogenic germline loss-of-function RUNX1 variants are known to be causative of autosomal dominantly inherited familial platelet disorder with a predisposition to hematologic malignancies (RUNX1-FPD, FPDMM, FPD/AML, ORPHA: 71290, MIM: 601399), also recognized in the 2016 WHO classification of myeloid neoplasms and acute leukemia [24]. This evidence concerns the gene RUNX1 and acute leukemia.