We also could not detect the direct binding between PRMT5 and HDAC2, suggesting that ZEB2 and TWIST1 recruit other components of NuRD complex through MTA2 (Figure 4E).These data strongly support the presence of the ZEB2/TWIST1/PRMT5/NuRD complex in CRC cells. Here, PRMT5 is linked to colorectal carcinoma.