TJP2 and neoplasm: Since no mutations were found in ABCB11, WES was performed on patients’ blood and tumour revealing homozygosity for c.817delG (p.A273Pfs*38) in TJP2. This mutation was predicted to cause a frameshift in all protein transcripts (Table 2) while expressions of TJP2 and claudin-1 were respectively absent and markedly reduced in nontumoral liver tissue