The outcome after vandetanib treatment in RET-positive patients, regardless of the treatment line, was consistent with previously reported results from our unselected cohort of 48 patients with advanced MTC undergoing MKI treatment with vandetanib and/or cabozantinib, which showed a median OS of 53 months and a median PFS of 17 months [13]. The gene discussed is RET; the disease is medullary thyroid gland carcinoma.