In an indirect comparison with the phase 1/2 trial of selpercatinib in patients with RET-positive MTC showing an ORR (objective response rate) of 69% and 72% in previously treated and not-treated patients by independent review, respectively, the ORR in our cohort ranged between 27% and 32% depending on the treatment line and compound [16]. Here, RET is linked to medullary thyroid gland carcinoma.