FOXO3 and neoplasm: Many circRNAs have been described in this regard: it was demonstrated that high expression of circWHSC1 in OC promotes tumorigenesis by sponging miR-145 and miR-1182 and that circWHSC1 shuttled by EVs induces tumor metastasis; circMUC16 promotes autophagy of OC via interaction with ATG13 and miR-199a, and its expression has been linked to the progression in stage and grade of OC [134]; circRNA forkhead box O3 (circ-Foxo3) promotes OC progression through EV-mediated intercellular interaction to target miR-422a/PLP2 axis and can also be considered a potential biomarker for OC [135].