ST-EPN-RELA usually harbors the fusion protein of C11orf95 and RELA and, in ST-EPN-YAP1 ependymoma, the transcriptional coactivator YAP1 fuses with other genes such as MAMLD1 and FAM118B, resulting in the upregulation of tumor promoting signaling pathways [12,13,14,15,42,43,44]. The gene discussed is RELA; the disease is neoplasm.